Welcome to Dr. Shehadeh's Laboratory
Our lab is focused on rare kidney disease, cardiovascular disease, Duchenne Muscular Dystrophy, and cardiac regeneration. We investigate the role of Osteopontin (OPN) and its downstream effectors in a variety of small and large animal models. We utilize cutting-edge techniques such as antibody-, aptamer-, and AAV gene- therapy in surgical and genetic mouse models. We routinely use extracellular flux analysis, echocardiography, left ventricular catheterization , patient-derived iPSC differentiation, and a variety of biochemical assays to study cardiac/renal function, mitochondrial function and a variety of mechanistic studies.