Our lab is focused on rare kidney disease, cardiovascular disease, Duchenne Muscular Dystrophy, and cardiac regeneration. We investigate the role of Osteopontin (OPN) and its downstream effectors in a variety of small and large animal models. We utilize cutting-edge techniques such as antibody-, aptamer-, and AAV gene- therapy in surgical and genetic mouse models. We routinely use extracellular flux analysis, echocardiography, left ventricular catheterization , patient-derived iPSC differentiation, and a variety of biochemical assays to study cardiac/renal function, mitochondrial function and a variety of mechanistic studies.