PUBLICATIONS

  1. Echocardiography Protocol: A tool for Infrequently Used Parameters in Mice. Frontiers in Medicine. In Press Frontiers in Cardiovascular Medicine. Emily Ann Todd*, Monique Williams*, Ali Kamiar, Monica Rasmussen, Shehadeh LA. *These two authors contributed equally. 2022.

  2. Severe Respiratory Failure and Lung Hyperinflammation in a Preterm Newborn with Perinatal SARS-CoV-2 Infection. Daniela Aguilar-Caballero, Veronica Caballero, Karen C Young, Shahnaz Duara, Michael Borchetta, Ivan Gonzalez, Ali G Saad, Jose MC Capcha, Shehadeh LA,  Emmalee S. Bandstra, and Augusto F Schmidt.Submitted. 2022.

  3. Autoimmune reaction associated with long COVID syndrome and cardiovascular disease: a genetic case report.  Anita Safronenka*, Jose MC Capcha*, Keith A Webster, Elena Buglo, Leonardo Tamariz, Jeffrey Goldberger, and Shehadeh LA. *These two authors contributed equally. PMCID: PMC9633038  JACC. September. 2022.

  4. A Mouse Model of Heart Failure with Preserved Ejection Fraction Driven by Hyperlipidemia and Enhanced Cardiac LDLR Expression. Monique Williams, Jose Manuel Condor Capcha, Camila Iansen Irion, Grace Seo, Guerline Lambert, Ali Kamiar, Rosemeire Kanashiro-Takeuchi, Lauro Takeuchi, Ali G Saad, Armando Mendez, Keith A Webster, Jeffrey J Goldberger,  Joshua M Hare, Shehadeh  LA.  JAHA. PMID: 36056728 September 3 2022.

  5. Col4a3-/- mice on Balb/C background have less severe cardiorespiratory phenotype and SGLT2 over-expression compared to 129x1/SvJ and C57Bl/6 background. Camila I Irion, Monique Williams, Jose Condor Capcha, Trevor Eisenberg, Guerline Lambert, Lauro M Takeuchi, Grace Seo, Keyvan Yousefi, Rosemeire Kanashiro-Takeuchi, Karen C Young, Joshua M Hare, Shehadeh LA.  PMID: 35743114. International Journal of Molecular Sciences. June 15 2022.

  6. Methylene Blue Is a Nonspecific Protein-Protein Interaction Inhibitor with Potential for Repurposing as an Antiviral for COVID-19. Sung-Ting Chuang, Henrietta Papp, Anett Kuczmog, Rebecca Eells, Jose Manuel Condor Capcha, Shehadeh LA, Ferenc Jakab, Peter Buchwald. PharmaceuticalsPMID: 35631447.  May 18 2022.

  7. S2 Heart Sound Identifies the Presence of Aortic Valve Calcification in a Mouse Model of Chronic Kidney Disease. Valentina Dargam, Hooi Hooi Ng, Sana Nasim, Daniel Chaparro, Camila Irion, Suhas Rathna Seshadri, Armando Barreto, Zachary Danziger, Shehadeh LA, and Joshua Hutcheson. Frontiers in Cardiovascular Medicine. PMID: 35694672May 25 2022.

  8. Peptide-Functionalized Dendrimer Nanocarriers for Targeted Microdystrophin Gene Delivery. Jessica Hersh , José Manuel Condor Capcha, Camila Irion, Guerline Lambert, Mauricio Noguera, Mohit Singh, Avinash Kaur, Emre Dikici, Joaquín J. Jiménez, Shehadeh LA, Sylvia Daunert, and Sapna K. Deo. Pharmaceutics. Dec. 2021PMID: 34959441

  9. Soluble guanylate cyclase stimulation mitigates skeletal and cardiac muscle dysfunction in a mdx model of Duchenne muscular dystrophy. Zhang L, Balke JE, Xu Y, Yousefi K, Irion CI, Alvarez RA, Krishnan SM, Stasch JP, Martinez EC, Buys ES, Sandner P, Shehadeh LA, Percival JM. BioRxiv. 2021https://www.biorxiv.org/content/10.1101/2021.02.14.431156v1

  10. Dual actions of β2AR-agonism confer protection against heart failure and renal dysfunction via inotropic and lusitropic effects and normalized cholesterol homeostasis in a mouse model of Alport Syndrome. Chahdi A*, Yousefi K*, Capcha J, Irion C, Lambert G, Shehadeh S, Dunkley J, Lee Y, Khan A, Ramic M, Andrade N, Zeier Z, Dykxhoorn D, Katsoufis C, Freundlich M, Hare JM, Nabity M, Rivera C, Lymperopoulos A, Keith A Webster, and Shehadeh LA*. Addressing Reviews. 2021.

  11. Development and piloting of an instructional video quality checklist (IVQC). Schooley SP, Tackett S, Peraza LR, and Shehadeh LA. Medical Teacher. Oct 19 2021. DOI: 10.1080/0142159X.2021.1985099. PMID: 34666585. 2021 

  12. Use of commercially-produced medical education videos in a cardiovascular curriculum: Multiple cohort study. Tackett S, Green D, Dyal M, O’Keefe E, Thomas T, Nguyen T, Vo D, Patel M, Murdock C, Wolfe E, and Shehadeh LA*. JMIR Med Educ. 2021 Oct 7;7(4):e27441. doi: 10.2196/27441. PMID: 34617911 2021.

  13. Small-Molecule Inhibitors of the Coronavirus Spike ­– ACE2 Protein-Protein Interaction as Blockers of Viral Attachment and Entry for SARS-CoV-2. Damir Bojadzic, Oscar Alcazar, Jinshui Chen, Sung-Ting Chuang, Jose M. Condor Capcha, Shehadeh LA, and Peter Buchwald. ACS Infect. Dis. May 12 2021PMID: 33979123.

  14. Dunkley JC*, Irion CI*, Yousefi K, Shehadeh SA, Webster KA, Goldberger JJ, and Shehadeh LA*. Carvedilol and Exercise Combination Therapy Improves Systolic but not Diastolic Function and Reduces Plasma Osteopontin in Col4a3-/- Alport Mice. AJP - Heart and Circulatory Physiology. 2021. PMID: 33769915.

  15. Kamiar A*, Yousefi K*, Dunkley JC*, Webster KA, and  Shehadeh LA*. β2-Adrenergic Receptor Agonism as a therapeutic strategy for kidney disease. AJP - Regulatory, Integrative and Comparative Physiology. Feb 2021. PMID: 33565369.

  16. Generation of SARS-CoV-2 Spike pseudotyped virus for viral entry and neutralization assays: A 1-week protocol. Capcha J, Lambert G, Dykxhoorn D, Gonzalez-Salerno A, Hare JM, Whitt MA, Pahwa S, Jayaweera DT, and  Shehadeh LA*. Frontiers in Cardiovascular Medicine, section Cardiovascular Metabolism. 15 January 2021. PMCID: PMC7843445PMID: 33521067.

  17. Hersh J, Broyles D, Capcha J, Lina A. Shehadeh LA, Daunert S, and Deo S*. Peptide-Modified Polymers: Overcoming Challenges to Therapeutic Applications. ACS Applied Bio Materials. Dec 24 2020. PMCID: PMC8267604

  18. Patel M*, Rodrigues D*, Yousefi K*, John-Williams K, Mendez AJ, Goldberg  R, Lymperopoulos A, Tamariz  LJ, Goldberger JJ, Myerburg RJ, Junttila J* and Shehadeh LA*. Osteopontin and LDLR are Upregulated in Hearts of Sudden Cardiac Death Victims with Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus. Front Cardiovasc Med. Nov 30 2020;7:610282. doi: 10.3389/fcvm.2020.610282. eCollection 2020 . PMID: 33330671.PMCID: PMC7734052

  19. Irion CI, Dunkley JC, John-Williams K, Condor J, Shehadeh SA, Pinto A, Loebe M, Webster KA, Brozzi  NA*, and Shehadeh LA*. Nuclear Osteopontin is a Marker of Advanced Heart Failure and Cardiac Allograft Vasculopathy: Evidence from Transplant and Retransplant Hearts. Frontiers in Physiology. 2020. 13 August; PMCID: PMC7438570

  20. Batlahally S, Franklin A, Damianos A, Huang J, Chen P, Sharma M, Duara J, Keerthy D, Zambrano R, Shehadeh LA, Martinez E, deFreitas M, Kulandavelu S, Abitbol C, Freundlich M, Kanashiro-Takeuchi R, Schmidt A, Benny M, Wu S, Mestan K, Young​ K. Soluble Klotho, a Biomarker and Therapeutic Strategy to Reduce Bronchopulmonary Dysplasia and Pulmonary Hypertension in Preterm Infants​. Scientific Reports. 2020.Jul 23;10(1):12368.doi: 10.1038/s41598-020-69296-1. PMID: 32704023

  21. Ali MF, Venkatarayappa SKB, Benny M, Rojas C, Yousefi K, Shehadeh LA, Kulandavelu S, Sharma M, Da Silva N, Freundlich M, Abitbol CL, DeFreitas MJ, Young KC. Effects of Klotho supplementation on hyperoxia induced renal injury in a rodent model of postnatal nephrogenesis. Pediatric Research 2020. Feb 14. doi: 10.1038/s41390-020-0803-z. PMID: 32059229

  22. Benny M, Hernandez DR, Sharma M, Yousefi K, Kulandavelu S, Batlahally S, Zambrano R, Chen P, Martinez EC, Schmidt AF, Shehadeh LA, Vasquez-Padron RI, Wu S, Velazquez OC, Young KC. Neonatal hyperoxia exposure induces aortic biomechanical alterations and cardiac dysfunction in juvenile rats. Physiol Rep. 2020 Jan;8(1):e14334. doi: 10.14814/phy2.14334. PMID: 31925922

  23. Yousefi K, Julian Dunkley, and Shehadeh LAA preclinical model for phenogroup 3 HFpEF. Aging (Albany NY). 2019 Jul 15. doi: 10.18632/aging.102102. PMID: 31305259.

  24. Yousefi K, Irion CI, Takeuchi LM, Ding W, Lambert G, Eisenberg T, Sukkar S, Granzier HL, Methawasin M, Lee DI, Hahn V, Kass DA,  Hatzistergos K, Hare JM, and Shehadeh LA. Osteopontin Promotes Left Ventricular Diastolic Dysfunction through a Mitochondrial Pathway. Journal of American College of Cardiology. 2019;73:2705–18. PMID: 31146816.

  25. Deletion of Osteopontin Enhances β2-Adrenergic Receptor-Dependent Anti-Fibrotic Signaling in Cardiomyocytes.  Celina M. Pollard,Victoria L. Desimine, Shelby L. Wertz, Arianna Perez, Barbara M. Parker, Jennifer Maning, Katie A. McCrink, Shehadeh L, and Anastasios Lymperopoulos. International Journal of Molecular Sciences. 2019, 20, 1396.​ PMID: 30897705

  26. Irion CI, Parrish K, John-Williams K, Gultekin SH, and Shehadeh L. Osteopontin Expression in Cardiomyocytes is Increased in Pediatric Patients with Sepsis or Pneumonia. . Frontiers in Physiology. December 2018 | Volume 9 | Article 1779. PMID: 30618794.

  27. Ritter P, Yousefi K, Ramirez J, Dykxhoorn D, Menez A, and Shehadeh L. LDL Cholesterol Uptake Assay Using Live Cell Imaging Analysis with Cell Health Monitoring. J. Vis. Exp. 2018 (141), e58564,doi:10.3791/58564. PMID: 30507918​.

  28. Ding W, Yousefi, K, and Shehadeh L. Isolation, Characterization, and High Throughput Respiration Assay of Mouse Primary Renal Tubular Epithelial Cells. J Vis Exp. 2018 Jun 20;(136). doi: 10.3791/57718. PMID: 29985358.

  29. Ding W, Yousefi, K, Goncalves S, Goldstein B, Sabater A, Kloosterboer A, Ritter P, Lambert G, Mendez, A, and Shehadeh L. Osteopontin Deficiency Ameliorates Alport Pathology by Preventing Tubular Metabolic Deficits. JCI Insight. 2018 3(6):e94818. PMID: 29563333. Featured in Nature Reviews Nephrology. April 2018PMID: 29643464.

  30. Kurtenbach S, Ding W, Goss GM, Hare JM, Goldstein BJ, and Shehadeh L. Differential Expression of MicroRNAs Among Cell Populations in the Regenerating Adult Mouse Olfactory Epithelium. PLoS One. 2017  Nov 6;12(11). PMID: 29107942. 

  31. Ding W, Shehadeh L. New incriminating evidence against IGF2. Transl Cancer Res 2017;6(Suppl 6):S949-S952doi: 10.21037/tcr.2017.06.07. 

  32. Li J*, Yousefi K*, Ding W, Singh J, Shehadeh L. Osteopontin RNA aptamer prevents and treats pressure overload-induced heart failure.Cardiovascular Research. 2017 May 1;113(6):633-643. doi: 10.1093/cvr/cvx016. . PMID: 28453726

  33. Alexander Grabner, Ansel P. Amaral, Karla Schramm, Saurav Singh, Alexis Sloan, Christopher Yanucil, Jihe Li, Lina A. Shehadeh, Joshua Hare, Valentin David, Aline Martin, Alessia Fornoni, Giovana Seno Di Marco, Dominik Kentrup, Stefan Reuter, Anna B. Mayer, Hermann Pavenstädt, Jörg Stypmann, Christian Kuhn, Susanne Hille, Norbert Frey, Maren Leifheit-Nestler, Beatrice Richter, Dieter Haffner, Reimar Abraham, Johannes Bange, Bianca Sperl, Axel Ullrich, Marcus Brand, Myles Wolf, and Christian Faul. Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. Cell Metabolism. 2015PMID: 26437603.

  34. Ding W, Li J, Singh J, Alif R, Vazquez-Padron RI, Gomes SA, Hare JM, Shehadeh L. miR-30e targets IGF2-regulated osteogenesis in bone marrow-derived mesenchymal stem cells, aortic smooth muscle cells, and ApoE-/- mice. Cardiovasc Res. 2015 Apr 1;106(1):131-42. doi: 10.1093/cvr/cvv030. Featured article (Editor’s Choice). PMID: 25678587.

  35. Hu X*, Wu R*, Shehadeh L*, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster K, and Wang J. Severe Hypoxia Exerts Parallel and Cell-type-specific Regulation of Gene Expression and Alternative Splicing in Human Mesenchymal Stem Cells. * Authors contributed equally. BMC Genomics.  2014. Apr 23;15(1):303. PMCID: PMC4234502.

  36. Rodriguez-Menocal L, Hafeez M, Shehadeh L, Duke J, Wei Y, Pena A, Martinez L, Gupta V, Pham S, and Vazquez-Padron R. Macrophage-derived IL-18 and increased fibrinogen deposition are age-related inflamatory signatures of vascular remodeling. American Journal of Physiology - Heart and Circulatory Physiology. 2014 Mar;306(5):H641-53. PMID: 24414074.

  37. Shehadeh L and Hare J . RNA Biomarkers for Heart Failure: Is There a Correlation Between Heart and Blood Transcriptomics? Journal of American Cardiac Cardiology (JACC) Heart Failure. JCHF. 2013;1(6):477-479. doi:10.1016/j.jchf.2013.10.002. PMID: 24592354.

  38. Shehadeh L, Sharma S, Wei JQ , Mitrani J, Pessanha M, Rodrigues R, Yuan HJ, Scherr M, Tsinoremas N, and Bishopric NH. MicroRNA-20a constrains p300-driven myocardial angiogenic transcription by direct targeting of p300. PloS ONE. 2013. PMID: 24236097.

  39. Shehadeh L, Webster K, Hare J, and Vazquez-Padron R (2011). Dynamic Regulation of Vascular Myosin Light Chain (MYL9) with Injury and Aging. PLoS ONE 6(10): e25855.doi:10.1371/journal.pone.0025855. PMID: 22003410.

  40. Rodriguez C, Shehadeh L, Calero K, Chopra I, Tsinoremas N, and Bishopric NH. Heterogeneity in SDF-1 Expression Defines the Vasculogenic Potential of Adult Cardiac Progenitor Cells. PLoS One. 2011;6(8):e24013. Epub 2011 Aug 24. PMID: 21887363.

  41. Wu Q, Ma Q, Shehadeh L, Wilson A, and Webster K (2010). Age-dependent regulation of Cell Division by the Argonaute Protein PiwL2 in Mouse Mesenchymal Stem Cells. BBRC, doi: 10.1016/j.bbrc.2010.05.022. PMCID: PMC3151571

  42. Wilson A, Shehadeh L, Hong Yu and Keith A Webster (2010). Age-Related Epigenetic Changes of Murine Bone Marrow Mesenchymal Stem Cells. BMC Genomics, 11(1):229. PMID: 20374652.

  43. Adi N, Mash DC, Ali Y, Singer C, Shehadeh L, Papapetropoulos S. Melatonin MT1 and MT2 receptor expression in Parkinson's disease. Med Sci Monit. 2010 Feb;16(2):BR61-7. PMID: 20110911.

  44. Shehadeh L, Yu K, Wang L, Burt A, Guevara A, Singer C, Vance J, and Papapetropoulos S. SRRM2, a Potential Blood Biomarker Revealing High Alternative Splicing in Parkinson’s Disease (2010). PloS One. 5(2): e9104. doi:10.1371/journal.pone.0009104. PMID: 20161708.

  45. Shehadeh L, Martin E, Scott W, Yu K, Wang L, Burt A, Guevara A, Singer C, Vance J, and Papapetropoulos S (2009). Finding Blood Biomarkers in Parkinson’s Disease using mRNA, miRNA, and SNP analysis. Nature Biotechnology Short Reports, v20, p57.

  46. Garamszegi N, Garamszegi S, Shehadeh L, and Scully S (2009) Extracellular Matrix Induced Gene Expression in Human Breast Cancer Cells. Molecular Cancer Research. 7(3): 319-29. PMID: 19276183

  47. Shehadeh L, N.Adi, N. H. Bishopric, and S. Papapetropoulos (2008). Expression of Lewy body protein septin 4 in postmortem brain of Parkinson´s disease and control subjects Movement Disorders.24(2): 204-10. PMID: 1895150

  48. Wei JQ, Shehadeh L, Mitrani J, Pessanha M, Slepak TI, Webster KA and Bishopric NH (2008) Quantitative Control of Adaptive Cardiac Hypertrophy by Acetyltransferase p300. Circulation. 118; 934-946. PMID: 18697823

  49. Shehadeh L, S. Sharma, J.Q. Wei, H. Yuan, S. Sitahal, K.A. Webster and N.H. Bishopric (2008). MiR-17~92 Cluster is Involved in the Angiogenic Switch in Cardiac Hypertrophy. Nature Biotechnology Short Reports, 19:99.

  50. Lesnick TG, Sorenson EJ, Ahlskog JE, Henley JR, Shehadeh L, Papapetropoulos S, Maraganore DM (2008). Beyond Parkinson disease: amyotrophic lateral sclerosis and the axon guidance pathway. PLoS ONE. 16;3(1):e1449. PMID: 18197259.

  51. T. G. Lesnick, S. Papapetropoulos, D. C. Mash, J. F. Mullen, Shehadeh L, M. de Andrade, J. R. Henley, W. A. Rocca, J. E. Ahlskog, and D. M. Maraganore (2007). A Genomic Pathway Approach to a Complex Disease: Axon Guidance and Parkinson's Disease. PLoS Genetics. 3(6):e98. PMID: 18197259.

  52. S. Papapetropoulos, A. Nikhil, Shehadeh L, D. C. Mash, N. H. Bishopric, C. Singer, A. A. Argyriou, and E. Chroni (2007). Is the G2019S LRRK2 mutation common in all south Euorpean populations? Journal of Clinical Neuroscience. PMID: 18617409

  53. C. O. Rodrigues, Shehadeh L, and N. H. Bishopric (2007). Myocyte Deficiency as a Target in the Treatment of Cardiomyopathy. Progress in Pediatric Cardiology. 23 (1-2).

  54. Papapetropoulos, Shehadeh L, and D. McCorquodale (2007). Optimizing human postmortem brain tissue gene expression profiling in Parkinson’s disease and other neurodegenerative disorders: From target “fishing” to translational breakthroughs. Neuroscience Research. PMID: 17503538

  55. S. Papapetropoulos, N. Adi, D. C. Mash, N. H. Bishopric, and  Shehadeh L (2007). Expression of α-Synuclein mRNA in Parkinson’s Disease. Movement Disorders.15;22(7):1057-9. PMID: 17373725.

  56.  Shehadeh L, N.H. Bishopric, A. Wilson, M. Gosink, N. Tsinoremas, and K.A. Webster (2007). Immune remodeling of mesenchymal stem cells during osteoblastic differentiation. Nature Biotechnology Short Reports, 18: 23.

  57. M. Pessanha, J.Q. Wei, Shehadeh L, J. Faysal, K.A. Webster, and N.H. Bishopric (2006). Cardiac myocyte p300 levels regulate myocardial angiogenesis. Nature Biotechnology Short Reports, 17:87.

  58. Shehadeh L, L. S. Liebovitch, and V. K. Jirsa (2006). Relationships between the Global Structure of Genetic Networks and mRNA Levels Measured by cDNA Microarrays. Physica A 364:297-314.

  59. Shehadeh L, L. S. Liebovitch, and M. A. Wood (2002). Temporal Patterns of Atrial Arrhythmia Recurrences in Patients with Implantable Defibrillators: Implications for Assessing Antiarrhythmic Therapies. Journal of Cardiovascular Electrophysiology 13: 4: 303 - 309. PMID: 12033342.

Book Chapters

1.       L. S. Liebovitch, L. A. Shehadeh, and V. K. Jirsa 2005. Patterns of Genetic Interactions: Analysis of mRNA Levels From cDNA Microarrays. Modeling in the Neurosciences: From Proteomics to Robotics, 2nd edition. Taylor and Francis, London. Ch2: 9-24

2.       L. S. Liebovitch, and L.A. Shehadeh 2005. Introduction to Fractals. In Tutorials in Contemporary Nonlinear Methods for the Behavioral Sciences Web Book Eds. M. A. Riley and G. V. Orden, National Science Foundation, Directorate for Social, Behavorial and Economic. Ch5.

3.       L. S. Liebovitch, V. K. Jirsa, and L. A. Shehadeh 2006. Structure of Genetic Regulatory Networks: Evidence For Scale Free Networks. Complexus Mundi: Emergent Patterns in Nature. World Scientific Publishing, Singapore. Ch1: 1-8.

4.       L. S. Liebovitch, L. A. Shehadeh, V.K. Jirsa, Marc Huett, and Carsten Marr 2010. Determining the Properties of Gene Regulatory Networks from Expression Data. Computational Methodologies in Gene Regulatory Networks. IGI Publishing. Ch17: 405-428.

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Peer-Reviewed Articles