Dr. Shehadeh’s laboratory is investigating the molecular mechanisms by which microRNAs regulate atherogenesis and stem cell differentiation. In parallel with the mechanistic studies, the Shehadeh lab is actively engaged in developing a targeted delivery method for microRNAs using aptamer technology. Dr. Shehadeh’s expertise in computational biology and data mining allows her to compile masses of genomic datasets to identify candidate genes and microRNAs with potential therapeutic functions. Her research has identified Osteopontin as a major regulator of heart failure and Alport pathologies. In addition to animal models, she uses translational tools such as AAV9 gene therapy, RNA aptamers, monoclonal antibodies, and patient-derived iPSC differentiation to reverse heart failure and prevent cholesterol influx in renal tubules.